Stearoyl Ethanolamide, CAS No.111-57-9

Basic Information

What is Stearoylethanolamide?

Stearoylethanolamide (SEA) is a fully saturated C18 N-acylethanolamines. N-acylethanolamines (NAEs), collectively called anandamides, constitute a class of lipid compounds. NAEs are naturally present in both animal and plant membranes as constituents of the membrane-bound phospholipid, N-acylphosphatidylethanolamine (NAPE).

Stearoylethanolamide (SEA) is an endocannabinoid neurotransmitter. It is present in human, rat, and mouse brain， its amounts comparable to those of the endocannabinoid anandamide (arachidonoylethanolamide, AEA).
SEA is the most abundant of several fatty acid ethanolamines produced by the PLD hydrolysis of phospholipids from mouse neuroblastoma cell membrane.

Function and benefits of SEA

Lose weight

Stearyl ethanolamide is a natural appetite suppressant for safe and effective weight Loss. It can inhibit the expression of stearoyl-CoA desaturase-1(SCD-1) mRNA.

SCD-1 is an iron-containing enzyme that catalyzes a rate-limiting enzyme in the biosynthesis of monounsaturated fats.

SCD-1 mRNA is expressed highly in white adipose, brown adipose tissue and the gland of Harder under non-fasting conditions. And the expression of SCD-1 in liver tissue and heart increased significantly under high carbohydrate diet.

Monounsaturated fatty acids are the products of SCD-1 catalyzed reactions. Monounsaturated fatty acids can be used as substrates for the synthesis of various kinds of lipids, including phospholipids and triglycerides.

Thus, the decrease of SCD-1 is beneficial to the increase of fatty acid oxidation and the reduction of fat production in skeletal muscle and liver.

Anti-inflammatory and anti-allergic

Stearyl ethanolamide has a significant inhibitory effect on auricle edema in adult mice induced by skin allergy. It is proved that stearyl ethanolamide (SEA) has anti-inflammatory properties.

The endogenous effect of stearoyl ethanolamide has not been fully elucidated. It does not combine with cannabinoid receptors, but it can affect cellular signals and trigger biological effects potentially through targets other than cannabinoid receptors. In 2001, some mouse research found that stearyl ethanolamide (SEA) acts on the ERK MAP kinase and then irritate AP-1 activity in mouse epidermal JB6 P+ cells. Although these pathways are not clear, stearoyl ethanolamide (SEA) has been found to strengthen AP-1 transcriptional activity mediated through the extracellular-signed-regulated protein kinase (ERK) mitogen-activated protein kinase (MAP kinase) pathway.

Promotes apoptosis of cancer cells

SEA can promote the apoptosis of cancer cells by inhibiting the expression of stearoyl-CoA desaturase-1(SCD-1) mRNA.

SCD1 is essential for lipid biosynthesis during the mitotic cell cycle; it provides new phospholipids for the biogenesis of cell membranes.

Over the past decade, SCD-1 has been extensively studied in cancer research and is considered as a new molecular target of broad-spectrum cancer molecular target.

Decrease of SCD-1 activity and mRNA expression damaged the formation of lipid in the cell membrane with the reduction of fatty acid biosynthesis and desaturation, which lead to cease tumor cell proliferation and induce cell apoptosis.

Help to treat metabolic diseases

SCD-1 is an essential point of metabolic control. Inhibition of its expression can promote the treatment of many metabolic diseases

SEA may help reduce adiposity, increase insulin sensitivity and resist the diet-induced obesity through inhibiting the expression of SCD-1.

FAQ:

What’s the difference between OEA and SEA in the mechanism?

Both of them can exert anorexic effects, but they show different receptor preferences. OEA decreases the food intake by activating the nuclear receptor PPARalph, while the anorexic effect of SEA was interestingly accompanied by the reduction in the liver (SCD-1) mRNA expression.

What’re the benefits of stearyl ethanolamide (SEA)?

Anorexic, appetite suppressant, Appetite Control, weight loss, apoptosis of cancer cell, Anti-inflammatory, and anti-allergic

Are there any other applications of stearyl ethanolamide (SEA) besides weight loss in the market?

Yes, SEA has very low solubility in aqueous environments, it has been used for many years as a pearling agent commonly referred to as ComperlanHS in cosmetic preparations.

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